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Annu Rev Physiol 57:707736 Moncada S, Bolanos JP (2006) Nitric oxide, cell bioenergetics and neurodegeneration

While this rapid initial loss is partly water weight and glycogen depletion, the metabolic signal to the body is the same

Urinary sodium and potassium levels were determined using Quantichrom Assay Kits (BioAssay Sytems) and then fractional excretion of sodium (FENa) and fractional excretion of potassium (FEK) were calculated using the corresponding formulas (Ashour et al., 2016)

One of the demonstrated mechanisms relies on the increase of cGMP level concomitantly with the activation of sGC during exercise